We've switched often. I thought I'd hate it, but I wouldn't have it any other way now. Even with two little kids who have needed naps, we've never had a problem. Even when switching for just one night, it was well worth it.
Sometimes we take the day off parks when we switch resorts mid-week. Then we do laundry enjoy at least one of the resort pools, if not both in one day, etc. This way packing in minimal because we wash it halfway through trip.
It's like two totally different vacations and has allowed us to try resorts we wouldn't have been able to afford for the entire week. We also love both Epcot and MK, so we get a MK resort and an Epcot resort for the best of both worlds.
Even when we don't take the day off from parks, we've barely noticed the loss in time. We check in first thing in the morning and leave our luggage at the front. When we take a break from the park our room is usually ready. Check-in, take a break and head to the next park.