Price it. One way rental with A NE drop off, in November is going to be $$$.
My guess, pick up at MCO will be the best rate. Renting the car when you arrive might not be that much more expensive then Renting for just a few days.
Edited to add you need to price the bottom line price. Some prices might have a large one way drop charge. Some may limit your free miles. Some may just charge more. Paying for excess miles might be the cheapest.
Agencies used to offer great One way rates driving TO FL in the fall and driving TO THE NE in the spring.