I'm pretty sure the EZ-Pass will be accepted in all states you might drive between NY and FLA, except SC. The good news is I don't think SC has any tolls for you to worry about! Of course, that's assuming you're driving. If not, you should be able to use your EZ-Pass in Florida and temporarily assign it to a rental car. In FLA, you can use EZ-Pass wherever you see SunPass or EPass signs, I believe.