At OKW it really depends on your personal preferences, I haven't had a bad room there. If you want to be near the first bus stop on the resorts route, request near Peninsular Road bus stop. Most villas have a golf course or pool view. Depending on bldg configuration, there are studios on 1st, 2nd, or 3rd floor. Request which would be most comfortable for you. However, by requesting 1st floor you might get assigned a wheelchair room (no tub, wheel-in shower). Personally, I try to avoid Bldg 20, 51 & 52 as those are bus turn around areas. If you are assigned bldg 20, I'd park near to bldg 21, that way your car isn't in danger of a 'bus strike'. Rare, but accidents do happen.
If you want to be near a quiet pool Turtle Pond has a snack bar with that pool, the other quiet pools do not. If you'll be taking to boat to DTD and want to be near Olivia's restaurant, request to be near Hospitality House.
Hope this helps.