I haven’t done the drive to wdw, but did drive from CT to Charleston about 7 - 8 years ago, and took I84 to Scranton, PA to 81, to 74 (I think) through Charlotte, NC, to 26, which intersects with 95 in SC. We took a couple of days to do some sightseeing on the way, but our total hours actually driving were about an hour less than a friend who drove (starting overnight to avoid traffic) from the same general area in CT to Myrtle Beach via 95 the same weekend. So we spent less time driving, even though we went further south. And it was a much prettier drive.
That said, I wouldn’t take that route in the winter, since it involves driving through a lot of mountainous areas in PA, VA, & NC.