I kind of hate spending that time on the road too, but with 5 of us, airfare from the metro NY area is like $3000 plus checked bags, and I hate that more than I hate spending the time driving lol.
For us, it is typically about 18 to 19 hours on the road, unless we get into serious traffic. It takes us about 20 minutes to get to the Palisades Parkway, then we go to 87, and over to 95 from there, and then straight down 95. Usually our first day driving is about 12 hours. We drive from the Mid Hudson Valley in NY to Manning SC, where we spend the night. That leaves us with a 6 hour drive the next day. The only places we ever really run into traffic are in NJ, right around DC, and then in the Northern part of VA. The rest of the drive is usually smooth sailing. We are past all of the areas where traffic is common on the first day. Our second day of driving is reliably 6 hours. We leave the hotel at just about 7 in the morning, and get into the Orlando / Disney area right around 1:00 in the afternoon.
If you use 95 through Virginia, I will say as soon as the EZPass express lane opens, get into it. If you opt not to use the EZPass express lane, then when you are nearing the point where that express lane merges back into the main lanes, get over to the right lane. The EZPass lanes merge in from the left, and often there is a backup at that merge point. When that happens, the left lanes go much slower than the right one, because all of the cars from the express lanes are merging into the left lane.
Beyond that, watch the speed, and enjoy the trip. I honestly don't mind the drive, and if my back isn't bothering me, it is pretty enjoyable.