Have driven with family since the 80s from Virginia. Won’t make specific hotels… but great stops with things to do and get yourself out of the car once you get to 95 are Dillon NC/south of the border. Savanah GA, fruit stand gift shop once you cross into FL (you will see it), Saint Augustine FL.
This all depends on your idea of a road trip of course. But even if I stayed overnight on a crunch ride and just wanted a quick breakfast on the way out I would pick these places over others.
From VA to Orlando.. my family has done it overnight many times but I do not recommend that. 1 night minimum 2 nights are way better.
Also sorry to say this but maybe just skip Jacksonville FL if it’s a budget hotel. Some can be pretty yikes. Like the worst imaginable. Has been that way for a long time.