Define “reasonable.” Eg Tom Bihn makes an outstanding product and they have great organization, but they are priced like they are made in America in small batches by fairly paid workers.
My go to travel backpack is an Osprey that I picked up at REI (currently there is a 20% off members sale going on). My work/commuter bag is a Belroy, that I got used from
Amazon. I have a couple of cheap travel duffels that I use as a gym bag but can also travel with, and just bought myself an Away Everywhere Bag from eBay (used) because I make bad decisions when my insomnia is bad. I like it but I think I prefer having a backpack to something on my roller bag.
The next backpack I buy will probably be sized for 3-4 days (40-50L) due to a couple of trips where a rolling suitcase would be inconvenient. I have one like that from eBags but the quality isn’t great and once again I’m not sleeping that well.