On the first evening you're on the ship, you'll pass over the Gulf Stream which tends to be more turbulent than other waters. We have noticed it as early as 6:30pm the first night. It ususally ends by 10 or 11pm and the seas are usually smoother after that.
I have an inner ear problem that can make me have the symptoms of seasickness almost anytime even on land. I take the prescription version of Meclizine 25 mg to help and it almost always works well.
I always make sure that I take a new dose of it soon after we pass over the bridge where you see the ship for the first time. This makes it approximately 45 minutes to an hour before I get on board and then I take another dose 4 hours after that to help with the Gulf Stream passage. By the time I could take another dose according to the label, we're back into smooth seas and it isn't necessary.
I also take Ginger Capsules on a regular basis and I take two in the morning and then two at night and I seldom need to take the prescription after the first night. Except for the day in St Thomas when I was on a shore excursion and at the mercy of a local driver when I was a passenger on a tour.
I have tried the wrist bands and haven't noticed much relief from them, but take them along just in case.
Like others, I would also encourage you to try out the medication a week before your cruise to make sure you don't encounter side effects that are unpleasant.
I also believe that the
DCL ships have superior stabilizers and from experience, I can say that you notice less motion than you would on another cruise line.
For cabin selection, I would also recommend an outside cabin that is midship and on a lower numbered deck for the center of gravity. If you'd like a veranda cabin which I think helps further, I recommend one on deck 5 or 6, the lowest decks with a veranda. I do believe that being able to see the horizon does help to lessen motion sickness and I do prefer being closer to the water on a low numbered deck.